Document Type : Original Article
Abstract
Ion channels in neurons and the transmitted signal between neurons are disrupted
by drugs or poison. To have insight into the regulation of deformed neuron function
by exceptionally low-frequency (ELF) magnetic field (MF), a generalized model of
Hodgkin and Huxley is presented which introduces ELF sinusoidal MF as an additive
voltage input. The Hodgkin and Huxley neuronal model is exposed to an ELF MF
to suppress the blocking of the sodium ion channel. By analyzing the average spiking
frequency and average spiking amplitude, it can be found that the effects of ELF MF
on neuronal activity will increase as the frequency and amplitude of MF increase. It
is shown that by blocking sodium channels, the amplitude and number of spikes of the
action potential are decreased. Results show that an ELF MF can increase INa which
indicates that toxic ion channels can be modulated and their impaired function can be
remedied
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